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Melatonin 2 (hamster) CEREP ligand profiling
Assay data:1 Tested
Summary
Agonist activity at hamster recombinant alpha-1B receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of forskolin-stimulated intracellular cAMP accumulation in CHO cells after 30 mins by FRET assay
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Agonist activity at hamster recombinant alpha-1B receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay relative to phenylephrine
Assay data:5 Tested
Effect on Ca2+ mobilization in GPR17 deficient CHOK1 cells at 3 uM after 20 mins by oregon green 488 BAPTA-1/AM dye-based fluorescence assay
Effect on Ca2+ mobilization in GPR17 deficient CHOK1 cells at 0.3 uM after 20 mins by oregon green 488 BAPTA-1/AM dye-based fluorescence assay
Assay data:2 Tested
Effect on Ca2+ mobilization in GPR17 deficient CHOK1 cells at 1 uM after 20 mins by oregon green 488 BAPTA-1/AM dye-based fluorescence assay
Effect on Ca2+ mobilization in GPR17 deficient CHOK1 cells at 0.1 uM after 20 mins by oregon green 488 BAPTA-1/AM dye-based fluorescence assay
Caspase-3/7 induction in CHO-K1 cells by small molecules, qHTS assay: Summary
Assay data:221 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Caspase-3/7 induction in CHO-K1 cells by small molecules, qHTS assay
Assay data:127 Active, 25 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Recovery of epirubicin following intraperitoneal epirubicin at 4 mg.Kg-1 dose in hamster
Recovery of 7-deoxy doxorubicin-aglycone following intraperitoneal epirubicin at 4 mg.Kg-1 dose in hamster
Recovery of 7-deoxy epirubicinol aglycone following intraperitoneal epirubicin at 4 mg.Kg-1 dose in hamster
Recovery of epirubicinol following intraperitoneal epirubicin at 4 mg.Kg-1 dose in hamster
Recovery of doxorubicinol following intraperitoneal epirubicin at 4 mg.Kg-1 dose in hamster
Recovery of epirubicin-glucuronide following intraperitoneal epirubicin at 4 mg.Kg-1 dose in hamster
Recovery of epirubicinol-glucuronide following intraperitoneal epirubicin at 4 mg.Kg-1 dose in hamster
Reduction of DPDPE-mediated total inositol phosphate production in CHO cells expressing human mu opioid receptor at 10 uM after 30 mins by scintillation counting analysis in presence of [3H]inositol
Reduction of U50,488-mediated total inositol phosphate production in CHO cells expressing human mu opioid receptor at 10 uM after 30 mins by scintillation counting analysis in presence of [3H]inositol
Effect on total inositol phosphate production in CHO cells expressing human mu opioid receptor at 10 uM after 30 mins by scintillation counting analysis in presence of [3H]inositol
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